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This review will cover inpatient and outpatient management.
Geometric mean antibody titers (GMTs) 1 month after the third dose were noninferior for HPV 6, 11, 16, and 18; in the 9v HPV group, 99% seroconverted to all nine HPV vaccine types (Table 3). One compared 9v HPV in approximately 2,400 females and males aged 9 through 15 years with approximately 400 females aged 16 through 26 years.
Over 99% seroconverted to all nine HPV vaccine types; GMTs were significantly higher in adolescents aged 9 through 15 years compared with females aged 16 through 26 years.
Few cases were caused by HPV 6, 11, 16, or 18 in either vaccine group.
Noninferior immunogenicity of 9v HPV compared with 4v HPV was used to infer efficacy for HPV 6, 11, 16, and 18.
9v HPV Efficacy, Immunogenicity, and Safety In a phase III efficacy trial comparing 9v HPV with 4v HPV among approximately 14,000 females aged 16 through 26 years, 9v HPV efficacy for prevention of ≥CIN2, vulvar intraepithelial neoplasia grade 2 or 3, and vaginal intraepithelial neoplasia grade 2 or 3 caused by HPV 31, 33, 45, 52, or 58 was 96.7% in the per protocol population* (Table 2) (2,16).
Efficacy for prevention of ≥CIN2 caused by HPV 31, 33, 45, 52, or 58 was 96.3% and for 6-month persistent infection was 96.0% (16).
9v HPV and 4v HPV are licensed for use in females and males.
Bivalent HPV vaccine (2v HPV), which contains HPV 16, 18 VLPs, is licensed for use in females (1).
Vaccination is also recommended through age 26 years for men who have sex with men and for immunocompromised persons (including those with HIV infection) if not vaccinated previously (1).
9v HPV is a noninfectious, virus-like particle (VLP) vaccine.