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Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size.If those genes don't work, babies are born with severely small brains, called microcephaly.

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That the defining feature of humans — our large brains — continued to evolve as recently as 5,800 years ago, and may be doing so today, promises to surprise the average person, if not biologists.

"We, including scientists, have considered ourselves as sort of the pinnacle of evolution," noted lead researcher Bruce Lahn, a University of Chicago geneticist whose studies appear in Friday's edition of the journal Science.

"There's a sense we as humans have kind of peaked," agreed Greg Wray, director of Duke University's Center for Evolutionary Genomics.

"A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.

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